The reversal of epidural morphine induced somnolence with physostigmine
نویسندگان
چکیده
منابع مشابه
Epidural nalbuphine for post cesarean epidural morphine induced pruritus.
OBJECTIVE The aim of the present study was to test the efficacy of epidural nalbuphine 5 mg for prevention of morphine-induced pruritus. MATERIAL AND METHOD Parturients, ASA I-II scheduled for elective cesarean section under epidural anesthesia were randomized into 3 groups: the placebo group, N-5 group, and N-10 group received 4 ml epidural solution containing morphine 4 mg plus either salin...
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In this study the effect of adrenergic receptor agonists and antagonists on physostigmine induced yawning was investigated. Intraperitoneal injection of different doses of physostigmine (0.03, 0.05, 0.1 and 0.2 mg/kg) caused yawning in white rats. The greatest response was seen at a dose of 0.2 mg/kg physostigmine. Phenylephrine, an α1 agonist, and clonidine, an α2 agonist, led to a decrease in...
متن کاملPhysostigmine induced reversal of ischemia following acute middle cerebral artery occlusion in the rat.
Cerebral cortical ischemia was induced in anesthetized rats by occlusion of the middle cerebral artery (MCA). Cerebral blood flow (CBF) was measured with the H2 clearance technique in the center and periphery of the ischemic territory. A decrease of CBF to about 50% of pre-occlusion values was observed in both areas. Administration of Physostigmine, a cholinesterase inhibitor, at a dose of 0.15...
متن کاملPhysostigmine antagonizes morphine-induced respiratory depression but not analgesia in dogs and rabbits.
The ability of physostigmine to antagonize the respiratory depressant effect of morphine was studied in conscious rabbits and ketamine-anaesthetized dogs pretreated with atropine methyl nitrate. Morphine 4 mg kg-1 increased PaCO2 in the rabbit from 3.43 +/- 0.16 to 4.95 +/- 0.28 kPa, decreased arterial pH from 7.45 +/- 0.01 to 7.31 +/- 0.01 and decreased respiratory frequency by 36%. Physostigm...
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1984
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03008766